Medicine research news Return to previous page
Article Released Thu-9th-March-2017 07:26 GMT
Contact: University of Malaya Institution: University of Malaya
 Medicinal properties of Tiger Milk Mushroom (TM02)

Preliminary tests by University of Malaya researchers on tiger milk mushroom powder extract (TM02) on rats indicate it may be useful for respiratory diseases and breast cancer treatment.

Figure 1
An example of tiger milk mushroom (whole mushroom).
Copyright : Associate Prof. Dr. Fung Shin Yee
Tiger milk mushroom (Lignosus rhinocerotis) is a valuable traditional medicinal mushroom in China, East Africa, Sri Lanka, Thailand, Philippines, Indonesia, Papua New Guinea, Australia, Vanuatu, and Malaysia. This popular medicinal mushroom has been used by the indigenous communities of Southeast Asia as a tonic to maintain general health, boost immunity and as treatment for numerous ailments including cancer, asthma, and bronchitis. Some communities also use it to treat discomfort caused by fright, fever, coughing, vomiting, and cuts. However, there has been little scientific data for tiger milk mushroom.

In 2009, University of Malaya researchers and their industrial collaborators have successfully cultivated and identified the DNA sequences that produce the proteins in the tiger milk mushroom. The research has been awarded the gold medal recipient of ITEX 2011 and also as the prestigious Prix Du Salon International Des Inventions De Geneva recipient by Salon International Des Inventions De Geneva in 2011 with several patents in the pipeline.

One issue that researchers face is that the supply of wild type tiger milk mushroom is erratic and with inconsistent nutritive quality that depends on the harvest time of the sclerotium. The sclerotium is the compacted, hardened fungal mycelium containing food reserves. Sclerotium requires at least 6 months for formation and is prized as it contains a higher medicinal property compared to other parts of the mushroom. The University of Malaya powder extract of this is called TM02, which is grown using food based materials in a hygienic and controlled environment, and later harvested at optimum condition, hence retaining its high medicinal properties.

Clinical tests of TM02 on rats indicate the sclerotial powder of tiger milk mushroom extracted by researchers in University of Malaya is safe for consumption and have anti-cancer and anti-inflammatory properties. Further work is underway to explore the mechanism action of TM02 and its bioactive components.

Research outlook:

Active research is on-going as a continuous effort by the Medicinal Mushroom Research Group (MMRG) to validate the superiority of this mushroom for health and well-being. The MMRG also welcomes collaborative efforts.

Contact Information

Associate Prof. Dr. Fung Shin Yee
Medicinal Mushroom Research Group (MMRG)
Department of Molecular Medicine
Faculty of Medicine
University of Malaya
50603 Kuala Lumpur, Malaysia

Email :
Figure 2
The sclerotia of tiger milk mushroom.
Copyright : Associate Prof. Dr. Fung Shin Yee

Journal information

References of related publications:

1. Vignesraaj Pushparajah, Ayesha Fatima, Chin Hung Chong, Thandeka Z Gambule, Chong Joo Chan, Szu Ting Ng, Chon Seng Tan, Shin Yee Fung, Sook Shien Lee, Nget Hong Tan, and Renee Lim (2016) Characterisation of a New Fungal Immunomodulatory protein from Tiger Milk mushroom, Lignosus rhinocerotis, NATURE Scientific Reports 6:30010
2. Hui-Yeng Yeannie Yap, Shin-Yee Fung, Szu-Ting Ng, Chon-Seng Tan, Nget-Hong Tan (2015) Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium, International Journal of Medical Sciences 12(1):23-31
3. Hui-Yeng Y. Yap, Shin-Yee Fung, Szu-Ting Ng, Chon-Seng Tan, Nget-Hong Tan (2015) Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium, Journal of Ethnopharmacology 174(2015)437 -451
4. Sook Shien Lee, Nget Hong Tan, Shin Yee Fung, Si Mui Sim, Chon Seng Tan, Szu Ting Ng (2014) Anti- inflammatory effect of the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden, the Tiger Milk mushroom, BMC Complementary and Alternative Medicine 14:359 (8 pages)
5. Yeannie HY Yap, NgetHong Tan, ShinYee Fung, Azlina A Aziz, ChonSeng Tan and SzuTing Ng (2013) Nutrient composition, antioxidant properties, and anti- proliferative activity of wild type and cultivated strain of Lignosus rhinocerus Cooke (Tiger milk mushroom) sclerotium, Journal of the Science of Food and Agriculture 93(12):2945-2952
6. Sook Shien Lee, Francis Kanyan Enchang, Nget Hong Tan, Shin Yee Fung, Jayalakshmi Pailoor (2013) Preclinical toxicological evaluations of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom, Journal of Ethnopharmacology,147 (157-163)
7. Lee, M.L., Tan,N.H., Fung, S.Y., Tan, C.S. and Ng, S.T. (2012) The anti-proliferative activity of sclerotia of Lignosus rhinocerus (tiger milk mushroom). Evidence- Based Complementary and Alternative Medicine Volume 2012 (2012), Article ID 697603, 5 pages doi:10.1155/2012/697603

Keywords associated to this article: tiger milk mushroom, Lignosus rhinocerotis, sclerotium, TM02
Create Account...