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 Dr Chan Young Park
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Name:
Dr Chan Young Park

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Country:
Korea, Republic Of

Institution:
Languages:
Korean, English

Areas of expertise:
Calcium Channel, SOCE, STIM, Orai, immune, neuroscience, voltage gated calcium channel

Biography:
The goal of our research is to understand the calcium signaling in cells. Calcium channels are a diverse group of proteins that regulate a wide range of signaling cascades by controlling calcium entry into cells. Numerous vital physiological processes such as cell division, proliferation, apoptosis, gene transcription and immune cell activation are regulated by calcium channels. Consequently, calcium channels are important for many pathological processes and diseases including autism, immune deficiency syndrome and cardiovascular diseases. In non-excitable cells, such as lymphocytes, mast cells, and platelets, calcium influx occurs primarily through store operated calcium channels (SOCs). We are interested in the dynamic calcium signaling events mediated by voltage gated calcium channels (VGCCs) and store operated calcium channels (SOCs).


Research Interests
Understanding calcium dynamics in various cells and developing novel channel blockers
Understanding the mode of action of SOCE; the function of STIM and Orai isoforms in the immune response.
Understanding the function of voltage gated calcium channel (VGCC) in neurons
Developing STIM1/Orai1 blocker; novel Orai1 calcium channel blockers for the anti-thrombotic and immunosuppressive drug.

Curriculum Vitae

2010 ~Present: Assistant Professor, UNIST
2010~2011: Research Associate/Visiting Professor, Department of Neurobiology, Stanford
2009~2010: Research Associate, Department of Neurobiology, Stanford
2004~2009: Postdoctoral Fellow, Department of Neurobiology, Stanford
2003~ 2004: Postdoctoral Fellow, Biochemistry, Gyeongsang Nat’l Univ.
2003: Ph.D. Biochemistry, Gyeongsang Nat’l Univ.
1999: M.S. Biochemistry, Gyeongsang Nat’l Univ.
1997: B.S. Biochemistry, Gyeongsang Nat’l Univ.

Awards/Honors/Memberships

Member of The American Society for Cell Biology
Member of Biophysical Society
2009: Robert Smittcamp CVI Postdoctoral fellowship. Stanford
2008~2011: SPARK program grant, Stanford
2006~2007: Dean’s Fellowship, Stanford
2005: KOSEF Fellowship

Publications:
1. C. Y. Park, A. Shcheglovitov, R. Dolmetsch (2010) The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels. Science. 330: 101-105

2. F. Mullins*, C. Y. Park*, R.E. Dolmetsch and R.S. Lewis. (2009) STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Proc. Natl. Acad. Sci. USA.106(36):15495-15500 Published online before print August 21, 2009 (*co-first authors)

3. C. Eroglu, N. Allen, M. W. Susman, N. A. O’Rourke, C. Y. Park, E. Ozkan, C. Chakraorty, S. B Mulinyawe, D. S. Annis, A. D. Huberman, E. M. Green, J. Lawlet, R. Dolmetsch, K. C. Garcia, S. J. Smith, Z. D. Luo, A. Rosenthal, D. F. Mosher and B. A. Barres (2009) The Gabapentin Receptor α2δ1 is the Neuronal Thrombospondin Receptor Responsible for Excitory CNS synaptogenesis. Cell 139: 380-392

4. C. Y. Park*, P.J. Hoover*, F. Mullins, P. Bachhawat, E.D. Covington, S. Raunser, T. Walz, K.C. Garcia, R.E. Dolmetsch, and R.S. Lewis, (2009) STIM1 Clusters and Activates CRAC channels via Direct Binding of a Cytosolic Domain to Orai1. Cell 136:876-890 (*co-first authors)

5. C. Y. Park and R.E. Dolmetsch, (2006) Cell signaling. The double life of a transcription factor takes it outside the nucleus. Science 314: 64-65

 
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