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 Dr Kyung-Tai Min
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Name:
Dr Kyung-Tai Min

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Country:
Korea, Republic Of

Institution:
Languages:
Korean, English

Areas of expertise:
protein synthesis morphological changes mitochondrial transport

Biography:
Our lab is interested in understanding the underlying cellular and molecular networks in normal and dysfunctional neurons affecting distinct brain functions. To this end, we are working on two projects: i) investigate local protein synthesis in neurons that underlies spine morphogenesis and synaptic plasticity and ii) identify the cellular and molecular mechanisms of mitochondrial trafficking as well as biogenesis in normal and disease cells.

Scientists do not yet understand how local protein synthesis regulates dendritic spine morphology, a process that is important for learning and memory. Numerous neurological disorders - including mental retardation - show morphological changes in dendritic spines. Until such understanding is acquired, the molecular link between dysregulation of local protein synthesis and the pathological changes in dendritic spines that lead to mental retardation will remain largely elusive. Our long-term goal is to better understand the fundamental molecular and cellular mechanisms that underlie mental impairment. The objective of immediate goal is to determine the underlying molecular mechanisms of local protein synthesis regulating dendritic spine morphology during neuronal stimulation.

Curriculum Vitae
2012~Present: Professor, UNIST
2007~2012: Associate Professor, Indiana University, Bloomington
2000~2007: Principal Investigator, NINDS, NIH
1999~2000: Staff Scientist, Caltech
1996~1999: Senior Research Fellow, Caltech
1994~1996: Postdoctoral Fellow, Caltech
1990~1993: Ph.D. University of Oxford

Awards/Honors/Memberships
2004: Society of Biochemical/CKD award
2001: Ellison Medical Foundation Young Investigator Award
2001: Special Acts of Service, NIH
1994: Del Web Foundation Fellowship
1990: Imperial Chemistry Industry Scholarship
Executive secretary, Association of Korean Neuroscientists

Publications:
Wang, W., Zhu, J, Chang, T, and Min, K-T. (2012) DSCR1 interacts with FMP and is required for spine morphogenesis and local protein synthesis. The EMBO Journal, 31. 3655-3666.

Chang, K, Robert F. Niescier, and Min, K-T. (2011). Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial mobility in axons. Proc. Natl. Acad. Sci. USA. 108, 15456-15461.

Todd P., Oh S., Krans A., Pandey U., DiProspero N., Min K-T, Taylor J., and Paulson H. (2010). Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of Fragile X Tremor Ataxia Syndrome. PLoS Genetics. 6. E1001240.

Chang, K, and Min, K-T. (2009). Up-regulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome.
Proc. Natl. Acad. Sci. USA. 106. 17117-17122.
 
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